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Accutane Side Effects: Should Depression Be A Concern?
Medical professionals and acne-pestered adolescents have no doubts about the effectiveness of the severe acne drug isotretinoin. It's the looming possibility of side effects such as depression and fetal damage that makes people uneasy when considering using this medication. Accutane (isotretinoin) is one of Hoffman-LaRoche's most popular and controversial pharmaceuticals. This week, a study published in the Archives of Dermatology vindicated isotretinoin from causing depression. In this report, Christina Y. Chia, MD, from Saint Louis University Health Sciences Center, St. Louis, and colleagues examined whether patients with moderate to severe acne treated with isotretinoin experienced an increase in depressive symptoms compared with patients treated with a topical antibiotic, topical retinoid, and an oral antibiotic. Dr. Chia found that "The use of isotretinoin in the treatment of moderate-severe acne in adolescents did not increase depressive symptoms. On the contrary, our study shows that treatment of acne improves depressive symptoms". Five years earlier, in 2000, the isotretinoin-depression link still appeared misleading. That time, the Archives of Dermatology posted study, headed by Dr. Susan S. Jick, from the Boston University School of Medicine, which found no evidence that isotretinoin increases the risk for depression, suicide, or other psychiatric disorders. Even though isotretinoin finds ample support among dermatologists and psychiatrists, a host of parents, politicians and medical professionals hail isotretinoin as a medical misfortune. For instance, Dr. David J. Graham, the Associate Director for Science and Medicine in FDA's Office of Drug Safety, recently warned that Accutane should be taken off the market. And while there are few studies with any negative observations about isotretinoin, Dr. Douglas Bremner's research at of the Emory University School of Medicine has linked isotretinoin treatment with changes in brain function. At the conclusion of this study, published in the American Journal of Psychiatry, Dr. Bremner concurred with Dr. Graham's view that isotretinoin proves too dangerous for human use. Dr. Bremner explains that to invoke depression, isotretinoin must influence the brain. During the investigation, brain function of the subjects was measured using positron emission tomography (PET) before and after four months of treatment with isotretinoin. Isotretinoin treatment was associated with decreased brain metabolism in the orbitofrontal cortex- the area of the brain known to mediate symptoms of depression. Yet, there were no differences in severity of depressive symptoms between the isotretinoin and antibiotic treatment groups before or after treatment. The pessimistic effects of isotretinoin also caught the attention of Diane K. Wysowski PhD. Dr. Wysowski noted that in June 2000, isotretinoin ranked among the top 10 drugs linked to depression and suicide attempts in the FDA's Adverse Event Reporting System database. In 2001, Dr. Wysowski examined isotretinoin's depression inducing potential and posted her findings in the Journal of the American Academy of Dermatology. Dr. Wysowski concluded that more studies of isotretinoin are needed. She also advised patients and their parents to immediately report mood swings and symptoms that are suggestive of depression such as sadness, crying, loss of appetite, unusual fatigue, withdrawal, and inability to concentrate to their prescribing physician. These protective measures can avoid more serious side effects and permit appropriate treatment, including consideration of drug discontinuation and referral for psychiatric care. While dissension among researchers still exists about whether or not isotretinoin causes depression, one idea most of them can agree on is that more research on the side effects of isotretinoin are desirable. If you are not in the mood for being an isotretinoin guinea pig, Geoffrey Redmond MD, author of The Good News about Women's Hormones, suggests using hormone therapy and/or using Retin-A if isotretinoin seems too chancy for you. Health author and Stanford University graduate Naweko San-Joyz lovingly writes from her home in San Diego. Her works include "Acne Messages: Crack the code of your zits and say goodbye to acne" (ISBN: 0974912204) and the upcoming work "Skinny Fat Chicks, Why we're still not getting this dieting thing" (ISBN: 0974912212) for release in June of 2005. For useful acne self-help articles visit http://www.Noixia.com
Latest Acne News:Site: acne - Yahoo! News Search Results New study could bring relief to acne patients A breakthrough could be on the way for acne patients, yet experts at the North Carolina Research Campus are enrolling participants in a new study, using genetics to help find safer ways to treat acne. With the help of 250 participants, a M.U.R.D.O.C.K. study conducted by Duke University experts, could lead to new, safer ways to treat severe acne. Overweight linked to acne in teen girls NEW YORK (Reuters Health) - Overweight girls in their late teens were twice as likely as their normal-weight peers to report having a lot of acne in a large new survey of Norwegian teenagers that did not find the same link in boys. Some 3,600 young people in Oslo, aged 18 and 19, provided information on their pimples, weight, diet and other health and lifestyle factors. Only about a tenth of the ... Really? The Claim: Excess Weight Raises the Risk of Acne Researchers have found, once again, that weight gain and moderate to severe acne go hand in hand, particularly among young women. Acne Control Mask from End-ZitŪ - Fight Acne with a High Concentration of Sulfur; End-ZitŪ, The Zit Stops Here!Ū ABBE Laboratories best-selling END-ZITŪ Acne Control Mask is now available in a convenient 2.5oz. squeezable tube. Use as a spot treatment or apply to the entire face, back or any problem area. Visit [http://www.endzit.com __title__ Fight Acne Today] and see for yourself.Farmingdale, NY (PRWEB) January 31, 2012 ABBE Laboratories best-selling END-ZITŪ Acne Control Mask is now available in a ... Diet does matter when in comes to acne Recent studies suggest dairy products and high glycemic foods can worsen acne, while omega-3 fats may alleviate it Overweight girls more prone to acne Overweight girls may be more likely than other young people to develop acne THE QUESTION Acne has no definitive cause but an array of suspects, including hormones, heredity, stress, chocolate, makeup and more. Should being overweight be added to the list? Read full article >> Best Acne Treatment Limited Announces A New Site On The Best Acne Treatment This is a new site on acne infection that provides information on acne and the best ways to treat and prevent acne infection. (PRWeb February 02, 2012) Read the full story at http://www.prweb.com/releases/2012/2/prweb9145226.htm To fight acne, trim back carbs, omega-6 fatty acids If you struggle with acne, eating foods with a low glycemic index may help regulate your blood glucose, which researchers say can decrease the production of oil and lower hormone levels that can contribute to acne. Overweight Teen Girls May Have Higher Acne Risk Title: Overweight Teen Girls May Have Higher Acne Risk Category: Health News Created: 1/16/2012 6:06:00 PM Last Editorial Review: 1/17/2012 NZ-developed acne drug approved for sale in US by FDA A NZ developed medication for acne has been approved for sale in America. Site: Acne - Google News Tips for acne-free skin - Times of India
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